Molecular Analysis of the Sodium/Iodide Symporter: Impact on Thyroid and Extrathyroid Pathophysiology
نویسنده
چکیده
A. Generation of anti-NIS antibodies 1086 B. N-linked glycosylation of NIS: implications for the NIS secondary structure model 1087 C. Extracellular orientation of the NH 2 terminus of NIS 1087 D. Several hydroxyl-containing amino acid residues in the transmembrane segment IX (Ser-353, Thr-354, Ser-356, and Thr-357) are important for NIS function 1088 E. Electrophysiological analysis of NIS: mechanism, stoichiometry, and specificity 1088 F. The NIS inhibitor perchlorate is not translocated by NIS into the cell 1089 III.
منابع مشابه
Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology.
The Na(+)/I(-) symporter (NIS) is an intrinsic membrane protein that mediates the active transport of iodide into the thyroid and other tissues, such as salivary glands, gastric mucosa, and lactating mammary gland. NIS plays key roles in thyroid pathophysiology as the route by which iodide reaches the gland for thyroid hormone biosynthesis and as a means for diagnostic scintigraphic imaging and...
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